In 2007, the Intergovenental Panel on Climate Change (IPCC) has warmed 13 largest deltas in the world under the threats of Climate change and Sea level rise, in which the Mekong River Delta in Vietnam and the Mississippi Delta in USA as two deltas likely to suffer serious impacts. 
Due to the important of food security, economical, social and cultural roles in two deltas, on June 25th, 2008, Vietnam and United States have a joint declaration to establish a DRAGON institute – Mekong at CanTho University.

DRAGON is the abbreviation of Delta Research And Global Observation Network. DRAGON institute – Mekong is a member of the global DRAGON Network, based on the Mekong River Delta. The purposes of the establishing DRAGON network are to the cooperating and long-termed experience-sharing relationship between Mekong Delta and Mississippi Delta, the connecting point of activities of research, education and scientific knowledge exchanging to local, regional, national communities and other deltas in the world, in order to strengthen adaptive ability of human beings to natural disasters, stably developing the socio-economy and preserving the natural eco-system.

For kick-starting the collaboration as the joint declaration between two countries, on 20-21 November, 2008, CanTho University cooperated with the United States Geographical Survey (USGS) and US National Wetlands Research Center (NWRC) had a celebrating ceremony of DRAGON Institution – Mekong - CanTho University (in Vietnam also called the “Research Institute for Climate Change – CanTho University”) at CanTho University.
Parallel with the institute establishing procedures, CanTho University has formed special research units concerning climate change impacts to natural resources, environment, socio-economic as well as the adaptation capacity of the Mekong River Delta.

After establishing, DRAGON institute – Mekong – CTU has met several national and international partners for putting forward many ideas to exchange and collaboration. 
On December 16th, 2008, the UN World Meteorological Organization (WMO) said the year 2008 is likely to rank as the 10th warmest year on record since the beginning of the instrumental climate records in 1850. On December 17th 2009, UN chief Ban Ki-moon called 2009 "the Year of Climate Change". These give us the adaptation research issues to climate change and sea level rise are becoming a practical tangible and interest. 

As his mission on the leading institute in the Mekong River Delta, CanTho University and DRAGON institute – Mekong – CTU have pioneering steps in climate change research and have a short and long-term action plan.